Category Archives: Types of TRK mutations

Trk kinase domain nonsense mutations

A non-concern:  nonsense mutations in the TRK kinase domain? As we have reviewed earlier, nonsense mutations create premature translation stop condons. The end result is a truncated Trk that may or may not involve the active site. Toffalini and Demoulin

Trk activation loop mutations

In search of mutations that mimic autophosphorylation Toffalini and Demoulin (2010)  had some interesting comments on the need of phosphorylation of the 1-3 tyrosines on the Trk activation loop.  The most obvious effect of posphorylation would be the introduction of

Trk juxta membrane mutations

The Trk juxta membrane domain is coming out of the shadows and maybe telling us something about Trk fusion proteins In many structural reviews of the Trk family of receptor tyrosine kinases, the extracellular domains that bind growth factors are