Tag Archives: Trk

Trk activation loop mutations

In search of mutations that mimic autophosphorylation Toffalini and Demoulin (2010)  had some interesting comments on the need of phosphorylation of the 1-3 tyrosines on the Trk activation loop.  The most obvious effect of posphorylation would be the introduction of

Trk juxta membrane mutations

The Trk juxta membrane domain is coming out of the shadows and maybe telling us something about Trk fusion proteins In many structural reviews of the Trk family of receptor tyrosine kinases, the extracellular domains that bind growth factors are