Tag Archives: TrkB

Simple Trk Mutations in Colorectal Carcinoma

The discovery of the NTRK gene fusion by way of it’s colon cancer driving fusion protein is covered on another site.¬† The NTRK genes were discovered before the sparingly expressed kinases.¬† It is rather ironic that scientists looked at simple

Trk kinase domain nonsense mutations

A non-concern:  nonsense mutations in the TRK kinase domain? As we have reviewed earlier, nonsense mutations create premature translation stop condons. The end result is a truncated Trk that may or may not involve the active site. Toffalini and Demoulin